A cornerstone of Thambai's imagery stems from his own family's ancestral background in masonry. This lineage fuels his ongoing fascination with architecture, structural building processes, and the physical labor required for construction. Beyond architectural themes, his pieces delve into memory, cultural identity, and the struggles of marginalized communities. He masterfully blends traditional motifs inspired by Mughal miniatures and indigenous Pithora art with modern socio-political commentary.

Expanding his practice past standard canvases, he regularly experiments with mixed media, drawing, video art, and site-specific installations to engage diverse audiences. His acclaimed bodies of work have been showcased at prominent platforms like the India Art Fair. Through these multifaceted projects, Thambai continues to challenge viewers to reflect on heritage and modern societal issues.